GLS and cancer: 2001; Gnad et al. 2001). Conversely, blockage of Rho pathways leads to suppression of NF-κB activity (Segain et al. 2003). This relationship is becoming increasingly important in deciphering regulatory underpinning of one of the crucial elements of metabolic reprogramming of cancer cell – it’s greatly elevated glutamine metabolism - where, apparently, activation of the predominant isoform of mitochondrial enzyme glutaminase is substantially influenced by concomitant RhoGTPase signaling and NF-kB activation (Wilson et al. 2013).