NFKB1 and pachyonychia congenita: The rationale for undertaking this study was based on evidence showing that NF-κB is constitutively activated in PC cells, is a major transcription factor involved in metastasis to bone, and, importantly, DLC1expression suppresses proliferation of PC cells in vitro, and their growth in nude mice (Andela et al. 2003 Guan et al. 2008).