Loss of α-catenin in cancer cells results in increased cell proliferation and resistance to apoptosis (Liu et al. 2007; Lien et al. 2006) whereas variations in availability of either α-catenin or β-catenin were shown to influence functional status of NF-κB (Deng et al., 2002; Kobielak and Fuchs 2006; Solanas et al. 2008). Here, NFKB1 is linked to cancer.