Considerable evidence shows that expression of circadian genes are directly under the regulation of cGMP (Golombek, et al. 2004; Oster, et al. et al. 2003; Plano, et al. et al. 2012); thus, regulation of PDE6 in breast cancer cells by light or by Wnt5a signaling through Frizzled-2 and transducin, all of which we find expressed in breast cancer cells, could directly regulate the expression of circadian genes in these cells through alterations in cGMP levels. The gene discussed is FZD2; the disease is breast cancer.