It was also shown that PDE6 is expressed in murine F9 teratocarcinoma cells (Ahumada, et al. 2002) and that PDE6 in these cells as well as in melanoma cells (Bazhin, et al. 2010) is activated by the noncanonical Wnt signaling pathway through Wnt5a binding to Frizzled-2 receptors, leading to activation of transducin and subsequent activation of PDE6. The gene discussed is WNT5A; the disease is melanoma.