Examination of the expression of the PDE6 regulatory genes, shown in Figure 4B, also closely paralleled that seen in the breast cancer cell lines in that only very minimal expression for PDE6G was seen in any tissues, and no significant expression was seen for PDE6H at all, but considerable and significant expression was seen for PDE6D in all eight patients’ breast tumor tissues. The gene discussed is PDE6D; the disease is breast neoplasm.