POMC and Cushing syndrome due to macronodular adrenal hyperplasia: Adrenocorticotropic hormone (ACTH)-dependent Cushing's syndrome includes Cushing's disease and ectopic ACTH syndrome (EAS), with the latter resulting from an extrapituitary ACTH-secreting tumor such as a small-cell lung carcinoma, pheochromocytoma, or bronchial or thymic carcinoid (1).