Adrenocorticotropic hormone (ACTH)-dependent Cushing's syndrome includes Cushing's disease and ectopic ACTH syndrome (EAS), with the latter resulting from an extrapituitary ACTH-secreting tumor such as a small-cell lung carcinoma, pheochromocytoma, or bronchial or thymic carcinoid (1). Here, POMC is linked to small cell lung carcinoma.