INS and neoplasm: Pharmacotherapy options to control symptoms and for the group of patients with unresectable insulin-secreting tumours include diazoxide (which controls hypoglycaemia by inhibiting insulin release by the pancreas), somatostatin analogues (such as octreotide and lanreotide), and the mTOR inhibitor everolimus (which may act either by causing tumour regression or by having a direct effect on glycaemic control).