Eleven cases have been described in the literature, comprising five patients with prolactinomas (5), (6), (7), (8), (9), three patients with growth hormone (GH)-secreting adenomas (4), (10), (11), two patients with TSHomas (12) and one patient with a gonadotrophin-secreting tumour (13). This evidence concerns the gene GH1 and TSH-secreting pituitary adenoma.