As an additional mechanism, an increased expression of the divalent metal transporter 1 (DMT1) in the senile plaques of AD patients has recently been demonstrated, in APP/SS1 transgenic mice, and even in cellular lines overexpressing APP, all of which have been correlated with increased levels of iron in human cells exposed to Aβ and also in the C. elegans that also overexpress APP. Here, APP is linked to Alzheimer disease.