TNF and neoplasm: Cytokines, growth factors, and mediators released in these diseases and the developing tissue microenvironment, such as IL-6, IL-8, TNF-α, and NO, have been found to have deleterious properties that pave the way for epithelial mesenchymal transition (EMT), prevent apoptosis, and lead to the destruction of specific host cell-mediated immune responses against tumor antigens.