In our study, plasma insulin concentration was enhanced after globular adiponectin treatment which was associated with the decreased expressions of adipoR1/R2 in gAd-treated group as compared to T2DM group, suggesting that globular adiponectin may affect the expressions of adipoR1/R2 in skeletal muscle by stimulating insulin secretion. The gene discussed is ADIPOQ; the disease is type 2 diabetes mellitus.