Nevertheless, it is known that overexpression of Hsp27 and Hsp72 in tumor cells negatively regulates apoptosis by preventing recruitment of procaspase-9 and procaspase-3 and sequestration of cytostolic cytochrome c from Apaf-1 after its release from the mitochondrion, thereby preventing the assembly of the functional apoptosome. Here, APAF1 is linked to neoplasm.