PTGS2 and colorectal carcinoma: The selective COX-2 inhibitor nimesulide (10 μM) shifted to the right of the CRC for anandamide by a factor of 6; the effect elicited by the highest anandamide concentration was reduced by about 20 % (Fig. 4b; for pEC25, pEC50 and Rmax values, see Table 1).