MAGEA3 and melanoma: For instance, treatment with demethylating agents such as AZA and/or histone deacetylase inhibitors such as depsipeptide have been shown to increase the levels of expression of NY-ESO-1 in melanoma cells, leading to increased recognition by T cells transduced with anti-NY-ESO-1 and anti-MAGE-A3 TCRs [22], [41].