Although barely expressed in Gleason grade G2 adenocarcinoma (n=11), NWD1 was significantly up-regulated in G3 (n=166) (p<0.0001), G4 (n=68) (p<0.0001), and G5 (n=8) (p<0.0001) PCa specimens compared to the normal prostate glands (Figs. 3 D-K). This evidence concerns the gene NWD1 and posterior cortical atrophy.