While experimental manipulation of NWD1 expression in PCa and other types of tumor cell lines had some modest effects on NF-κB activity and cellular sensitivity to cytotoxic cytokines and DNA-damaging anticancer drugs, the most striking cellular phenotype that we uncovered for NWD1 was the profound dependence of LNCaP cells on NWD1 for their growth and survival in culture. This evidence concerns the gene NFKB1 and posterior cortical atrophy.