NFKB1 and neoplasm: While experimental manipulation of NWD1 expression in PCa and other types of tumor cell lines had some modest effects on NF-κB activity and cellular sensitivity to cytotoxic cytokines and DNA-damaging anticancer drugs, the most striking cellular phenotype that we uncovered for NWD1 was the profound dependence of LNCaP cells on NWD1 for their growth and survival in culture.