Although Tbx2 knockout mice display microphthalmia [41], akin to gdf6a loss-of-function models in various vertebrate homologs [43], [50], [51], [52], [53], and gdf6a signaling has been previously demonstrated to positively regulate tbx2b expression during ocular morphogenesis [45], our data indicate that in zebrafish disruption of tbx2b is not sufficient to augment the pathology of microphthalmia observed upon gdf6a disruption. Here, TBX2 is linked to microphthalmia.