ERVW-1 and infection: Key issues about how best to move forward include (1) optimization of gB immunization to induce greater protective neutralizing responses; (2) inclusion of additional envelope glycoproteins to induce broader neutralizing responses against other virologically relevant cell types (i.e., gH pentamer-mediated infection of epithelial and endothelial cells); and/or (3) targeting other parts of the HCMV proteome not involved in attachment/entry of susceptible cells.