Already established uPAR-mediated pathways include uPAR association with integrins, the key molecules that promote rearrangement of the actin cytoskeleton and cell movement.10 PCb1 cells, M6 melanoma cells and the three HEK-293 clones show an integrin pattern in line with previous observations (figure 6A) [26-30]. The gene discussed is PLAUR; the disease is melanoma.