In previous studies, we have shown that KCNE1-KCNQ1 channel open-state is stabilized by PIP2 and impairment of this stabilization by arginine neutralization at position 243, 539 or 555 in KCNQ1 is correlated with the long QT syndrome [10], [13]. The gene discussed is KCNQ1; the disease is Prolonged QT interval.