PTEN and malignant peripheral nerve sheath tumor: When the NF1-associated MPNST mouse model (Dhh; Nf1 fl/fl; Pten fl/fl) was treated with Everolimus or PD-901, survival was significantly prolonged from an average of 15.8 days with DMSO treatment, to 22.4 days with Everolimus and 19.5 days with PD-901 (p=0.032 and p=0.036, respectively) (Figure 2A).