CDKN2B and cancer: This SNP is located in CDKN2BAS1, a long noncoding RNA region, and near the cluster of two tumor suppressor genes, CDKN2A and CDKN2B. CDKN2BAS1 has been implicated in the development of multiple chronic diseases and cancers, due to the role of CDKN2A and CDKN2B in cell cycle inhibition, senescence, and stress-induced apoptosis (30).