Previous studies suggested that melanocytes in non-lesional skin of vitiligo patients displayed aberrant features [10], [35], [36], including sensitive to oxidative stress, easy to detach after skin friction and increased production of biologically active proteins among the senescence-associated secretory phenotype (SAPS), such as IL-6 and matrix metalloproteinase-3, compared with melanocytes from normal healthy controls. The gene discussed is MMP3; the disease is vitiligo.