IGF1 and male reproductive organ cancer: Some anti-angiogenesis related genes were essentially down-regulated in PC3 cells, i.e. MMP2 [27], TNF-alpha [28], CCL11 [29] and the potent pro-angiogenic factor IGF1 (9 fold down-regulation) which is deeply involved in prostate carcinogenesis [30,31] and identified as autocrine proliferation stimulus for hPCa cells [32].