IL-27 caused, in both cell lines, a significant down-regulation of a series of anti-angiogenesis related genes namely FGFR3 [21], PTGS1 [22] and, particularly, FLT1 [23], which has been reported to be firmly and strongly expressed in hPCa [24,25] and involved in cancer cell proliferation via autocrine VEGF signaling [26]. This evidence concerns the gene PTGS1 and cancer.