Similarly, it has been shown that in breast cancer cells, the microRNA miR-200a is able to target a sequence in the 3′UTR of the Keap1 mRNA, leading to a reduction in the level of Keap1 mRNA and protein, and a concomitant increase in the level of Nrf2 and increased transcription of the Nrf2-target gene NQO1 (Eades et al., 2011). Here, NFE2L2 is linked to breast cancer.