Another recent study, showed that carbamazepine, an anticonvulsant and mood-stabilizing drug used primarily in the treatment of epilepsy and bipolar depression, demonstrates anti-AD effect in APP/PS1 transgenic mice via mTOR-dependent pathway and increased autophagy, leading to reduced amyloid plaque load and Aβ42 levels [73]. The gene discussed is PSEN1; the disease is Alzheimer disease.