PSEN1 and Alzheimer disease: Moreover, arctigenin, derived from Arctium lappa, could reduce both Aβ production by β-site amyloid precursor protein cleavage enzyme 1, and enhance Aβ clearance by potentiated autophagy by inhibition of protein kinase B PKB/mTOR signaling, and AMPK activation, and improve memory in APP/PS1 AD mice [66].