PRL and premenstrual tension: The pathophysiology of PMS remains unknown, complex and multifactorial and yet to be fully clarified and may include the effect of progesterone on neurotransmitters such as serotonin, opioids, catecholamine and GABA, increased prolactin level or increased sensitivity to the effect of prolactin, insulin resistance, sensitivity to endogenous hormones, abnormal hypothalamic-pituitary-adrenal axis function, nutritional deficiencies, alteration of glucose metabolism, and fluid and electrolyte imbalance [13,16-18].