Immunohistochemical analysis with cytokeratin 20 (ck 20, clone ks 20.8, Novocastra Menarini), ck 7 (clone ov-tl 12/30, Dako), and cdx2 (clone AMT 28, Novocastra Menarini) defined two distinct profiles of positivity: ck20 positive, ck7 negative, and cdx2 positive for the colonic cancer, and ck20 negative, ck7 positive, and cdx2 negative for the liver (Figure 3). Here, CDX2 is linked to colonic neoplasm.