We observed that most of the compounds in the antimicrobial, cancer related drugs, pesticides, and PXR mediators classes up-regulated the expression of the transcripts, except cyclosprin A in the antimicrobial class, cytochalasin and vinblastine sulfate in the cancer-related drug class, dexamethasone and ketoconazole in the PXR mediators class. The gene discussed is NR1I2; the disease is cancer.