The 14 classes included anti-microbial reagents, cancer-related drugs, energetics (explosives), halogenated contaminants, hormones and endocrine disruptors, inflammatory mediators, lipid mediators and peroxisomal mediators, metals, oxidative stress mediators, pesticides, ployaromatic hydrocarbons, pharmaceuticals and protective care products (PPCPs), and pregnane X receptor (PXR) mediators. This evidence concerns the gene NR1I2 and cancer.