We here focused on apoptosis and necrosis of the three human glioblastoma cell lines U87MG (p53 WT), U251MG (p53 mutated), and T98G (p53 mutated) induced by conventional fractionated RT (5x2Gy, weekly dose) in combination with clinically achievable levels of TMZ. The gene discussed is TP53; the disease is glioblastoma.