Traditionally, the pathogenesis of CKD-MBD has been ascribed to a decline in 1,25-dihydroxyvitamin D (1,25(OH)2D) levels, leading to increases in serum parathyroid hormone (PTH) and subsequent alterations in calcium and phosphorus metabolism [6, 7]. The gene discussed is PTH; the disease is Marchiafava-Bignami disease.