Age (70.4 ± 6.1 versus 58.6 ± 10.0 years, P < 0.0001) and incidence of hypertension (82 versus 45%, P = 0.008), creatinine (1.06 ± 0.17 versus 0.77 ± 0.14 mg/dL, P < 0.0001), and cystatin C (0.96 ± 0.12 versus 0.74 ± 0.11 mg/dL, P < 0.0001) were significantly higher in the CKD cases than in the without CKD cases. The gene discussed is CST3; the disease is chronic kidney disease.