However laboratory parameters of inflammation like TLC and CRP were similar in both category-A and B. Reliance on these markers would have led to overtreatment, undesired exposure to antibiotics with antecedent consequences.4 In the study by Stojanovic et al.,19 the TLC could not differentiate SCA patients with invasive bacterial infection from those without it. This evidence concerns the gene CRP and autosomal dominant cerebellar ataxia.