Previously, Mirsaeidi et al, also did not find any significant association between IFNR1395 SNP and susceptibility to TB among Iranian studied cases.35 Also few studies declines the correlation of IFNGR1 polymorphism with M. tuberculosis, instead they proposed the correlation of IFNGR1 polymorphism with avirulent or M bovis BCG infection.25,36 These observations may outline the alternative pathways for enhancing host immune response against M. tuberculosis. The gene discussed is IFNGR1; the disease is tuberculosis.