As Th2 cells induce various immune responses (e.g., goblet cell hyperplasia, intestinal mastocytosis, local and systemic eosinophilia, and high production of IgG1 and IgE) in mice infected with intestinal nematodes, we tried to determine which components of Th2 immune responses are essentially required for rapid expulsion of S. venezuelensis. Here, IGHE is linked to Increased total eosinophil count.