Analyses of diffuse large B cell lymphomas (DLBCL) over a decade ago identified two distinct subtypes of those malignancies with different survival advantages, the activated B-like (ABC) and germinal center B-like (GCB) DLBCL by gene expression profiling, which indicated differential ARID3a expression in the two subsets (65). This evidence concerns the gene ARID3A and diffuse large B-cell lymphoma.