CDKN2B and endometriosis: In 2010, the first endometriosis GWAS was published on a Japanese dataset of 1907 cases and 5292 controls (Uno et al., 2010), providing genome-wide significant evidence for association of a variant in CDKN2B-AS1 (cyclin-dependent kinase inhibitor 2B antisense RNA) [rs10965235; odds ratio (OR) = 1.44 (95% confidence interval (CI): 1.30–1.59), P = 5.57 × 10−12].