TFE3 fuses with any of the following gene partners; papillary renal cell carcinomas (PRCC) [3], non-POU domain containing octamer binding (NONO), splicing factor proline/glutamine rich (PFS) [4], renal cell carcinoma chromosome 17 (RCC 17) [5], clathrin heavy chain (CLTC) [6] and an unknown gene present on chromosome 19 [7]. The gene discussed is TFE3; the disease is hereditary clear cell renal cell carcinoma.