APC and colorectal carcinoma: All plasma samples from patients showed CRC associated copy number changes (www.progenetix.org; [36]), such as loss of the chromosomal 5q22 region harboring the APC (adenomatous polyposis coli) gene (n = 1; P3_1 in Figure S1), and loss of chromosome arms 17p (n = 5; P1_2, P2_1, P4_1, P7_1, and P9_1 in Figure S1), and 18q (n = 7; P2_1, P3_1, P4_1, P6_1, P7_1, P8_1, and P9_1 in Figure S1).