In the present study, we genotyped 6 miR-SNPs in miRNA processing machinery genes including XPO5 (rs11077), RAN (rs14035), Dicer (rs3742330), TNRC6B (rs9623117), GEMIN3 (rs197412), GEMIN4 (rs2740348) in 108 surgically treated HCC patients and evaluated the impact of these miR-SNPs on HCC outcome. This evidence concerns the gene DICER1 and hepatocellular carcinoma.