We genotyped these 6 miR-SNP of miRNA processing machinery genes including XPO5 (rs11077), RAN (rs14035), Dicer (rs3742330), TNRC6B (rs9623117), GEMIN3 (rs197412), GEMIN4 (rs2740348) in 108 HCC patients and 80 healthy controls, no statistically significant association (p<0.05) between patients and healthy controls was detected (data not shown). The gene discussed is DICER1; the disease is hepatocellular carcinoma.