NFκB is a well-characterized transcription factor and mediator of cellular activation by inflammatory cytokines and chemokines, and in the context of hepatocellular carcinoma, miR-224 was shown to be upregulated by tumor necrosis-α (TNF-α) and miR-224 regulation linked to hepatocellular migration and invasion [31]. Here, NFKB1 is linked to hepatocellular carcinoma.