A previous study using luceriferase immunoprecipitation systems has shown different patterns of reactivity to a lytic antigen (K8.1) and latent antigens (LANA and v-Cyclin) in patients with KS as compared to patients with MCD [20], and it will be of interest to see how the multiplex assay discriminates among different KSHV disease states. This evidence concerns the gene KRT81 and Kaposi's sarcoma.