MYB and hepatocellular carcinoma: To explore the molecular mechanism by which miR-424 suppressed HCC cell line growth, migration and invasion, we identified c-Myb as a direct target of miR-424 in HCC cells, and this conclusion is supported by the following reasons: complementary sequence of miR-424 was identified in the 3′UTR of c-Myb mRNA; ectopic of miR-424 led to a significant reduction in c-Myb at the protein level; overexpression of miR-424 inhibited c-Myb 3′UTR luciferase report activity and this effect was abolished by mutation of the miR-424 seed binding site.