The expression levels of MKRN2 were generally higher in leukemia samples (P<0.05 in Ph–B-ALL, Ph+B-ALL, T-ALL and AML samples) compared with those in age-matched normal BM cells (n = 9), whilst RAF1 was higher in Ph–B-ALL and AML samples (P<0.05). This evidence concerns the gene MKRN2 and leukemia.