Nonetheless, in subjects with helminth infection the median proportion of HLA-DR+/CD38+ CD4 T cells was significantly elevated (2.16% versus 2.63%, p = 0.011) whereas median HLA-DR+/CD38+ CD8 T cell frequencies were moderately increased (5.50% versus 6.86%, p = 0.055). This evidence concerns the gene CD4 and helminthiasis.