IFNG and schistosomiasis: In contrast to drug-induced resistance to schistosomiasis, naturally acquired resistance has been reported in a subset of people who have constant exposure to schistosomes but have never been treated with PZQ (exemplified by the PR cohort in our study) – these individuals generate robust T cell responses against the surface of the larval schistosomulum and are characterized by elevated levels of IFN-γ [35], [56]–[58].