ALK and non-small cell lung carcinoma: The 3′ portion of the ALK gene is sometimes fused with the 5′ segment of the echinoderm microtubule-associated protein-like 4 (EML4) gene, which is associated with approximately 7% of non-small-cell lung cancer (NSCLC) cases [31], or it can associate with the 5′ region of the nucleophosmin (NPM) gene, found in approximately 60% of anaplastic large-cell lymphoma (ALCL) cases [32].