Furthermore, H-4073 mediated inhibition of STAT3, focal adhesion kinase (FAK), Akt and vascular endothelial cell growth factor (VEGF) signaling pathways and was able to sensitize tumor cells to the effects of cisplatin, resulting in inhibition of migration and apoptosis in vitro as well as reduction in tumor volume in vivo. The gene discussed is AKT1; the disease is neoplasm.