RB1 and hydrops fetalis: Rb1 treatment significantly increased anorexigenic pro-opiomelanocortin (POMC, +75%; p<0.05) and decreased orexigenic agouti-related protein (AgRP, -24%; p<0.05) mRNA expression in the mediobasal hypothalamus of HF mice, but had no effect on orexigenic neuropeptide Y (NPY) mRNA levels (Table 2).