TNF and hydrops fetalis: In the epididymal adipose tissue of HF mice treated with Rb1, we found significantly reduced expression of pro-inflammatory cytokines (TNF-α, -44%; IL-6, -25%; IL-1β, −30%; p<0.05), as well as the inflammatory signaling molecule p-IKK (−44%; p<0.001), compared to HF control mice (Fig. 3A).