Second, after 8 weeks of HF diet leptin did not suppress energy intake and body weight gain in HF control mice (Fig. 5B and E), while acute Rb1 treatment (2 days) restored leptin sensitivity, evidenced by a 41% reduction in energy intake and a very significant reduction in body weight gain following leptin icv injection compared to saline icv injection (p<0.05, Fig. 5B and E). The gene discussed is LEP; the disease is hydrops fetalis.