The possible mechanisms include: (1) Beclin 1 induces autophagy in ovarian cancer cells lacking apoptotic ability; (2) Beclin 1 stabilizes the mitochondrial structure and reduces the frequency of additional gene mutations [23]; and (3) Beclin 1 overexpression arrests the cell cycle, inhibits cell proliferation, and promotes autophagy and apoptosis. The gene discussed is BECN1; the disease is ovarian carcinoma.