The IFNAR−/− mice succumbed to the infection within 3 days but the phenotype in VSV-infected IRF-1−/− mice showed a different picture as IRF-1−/− mice survived only until day 7, indicating that although the type I IFN system is important in antiviral control of VSV, IRF-1 is also essential to control the infection. The gene discussed is IFNAR1; the disease is infection.