After stratification in AMD cases and controls, associations for the major risk variants in rs1061170 (CFHY402H, p = 0.35 for no AMD; p = 0.55 for AMD) and rs10490924 (ARMS2, p = 0.75 for No AMD, p = 0.25 for AMD) with the C3d/C3 ratio could not be observed. Here, C3 is linked to age-related macular degeneration.