In the first model, we included all SNPs (rs1410996, rs800292, rs12144939 in CFH, rs4151667 in CFB, rs6795735 and rs2230199 in C3) that had reached statistical signifcance in the individual analysis and the two major AMD risk SNPs risk ARMS2 rs10490924 and CFH rs1061170. This evidence concerns the gene C3 and age-related macular degeneration.