Variants in VEGFA rs699946, SLC16A8 rs8135665 and ADAMTS9-AS2 rs6795735 also showed a trend for a higher AMD risk without statistical significance, which also may be due to a smaller effect on AMD development for each of those SNPs compared to ARMS2 rs10490924 or CFH rs1061170. The gene discussed is ADAMTS9; the disease is age-related macular degeneration.