An involvement of JAK/STAT3 in the tumor suppressive senescence induced in developing breast lesions may have adverse consequences for the use of JAK/STAT3 signaling inhibitors, such as approved drugs tofacitinib or ruxolitinib, or drugs in clinical trials such as baricitinib, lestaurtinib, pacritinib, or TG101348. Here, STAT3 is linked to neoplasm.