When healthy donor human CD14+ monocytes were cultured with human glioblastoma cell lines, the glioblastoma-conditioned monocytes had immunosuppressive features, including reduced CD14 (but not CD11b) expression, increased secretion of interleukin-10, TGF-beta, and B7-H1 expression, decreased phagocytic ability, and increased ability to induce apoptosis in activated lymphocytes. This evidence concerns the gene CD274 and glioblastoma.