Furthermore, in CX3CR1−/− mice with intracranial gliomas, the number of infiltrated TAMs was similar to that in CX3CR1+/− mice, along with a slight increase in tumor growth in CX3CR1−/− mice [27], suggesting that microglia has little contribution in TAM infiltration and the GBM tumor growth. Here, CX3CR1 is linked to neoplasm.